Today we discuss the experience of returning home after timeway—culture shock, social media, and seeing your home with fresh eyes. Then a difficult set of topics: anorexia, physician assisted suicide, “terminal” diagnoses, social contagions, and what people have a right to do with their own lives. Finally: AI has been used to predict potentially useful drug combinations to fight cancer. What does this mean for the future of medicine, and AI?

988 Suicide & Crisis Lifeline: https://988lifeline.org

Free and confidential helpline for individuals and families facing mental disorders: https://www.samhsa.gov/find-help/helplines/national-helpline

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Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)

Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

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Mentioned in this episode:

Denver Post op-ed on Jane Allen: https://www.denverpost.com/2025/10/02/assisted-suicide-was-offered-to-my-friend-jane-allen-she-had-an-eating-disorder-opinion/

Gaudiani et al 2022. Terminal anorexia nervosa: three cases and proposed clinical characteristics. Journal of Eating Disorders, 10(1): 23: https://link.springer.com/content/pdf/10.1186/s40337-022-00548-3.pdf

Guarda et al 2022. Terminal anorexia nervosa is a dangerous term: it cannot, and should not, be defined. Journal of eating disorders, 10(1): 79: https://link.springer.com/content/pdf/10.1186/s40337-022-00599-6.pd

Mia Hughes’ tweet thread on social contagions: https://x.com/_CryMiaRiver/status/1491065839495544837

Laura Delano on DarkHorse: https://www.youtube.com/watch?v=18XtCdasn2Q&list=PLjQ2gC-5yHEuZwhHfjXu3KH8MomS2N3zq&index=13

Laura Delano’s book, Unshrunk, excerpted at Natural Selections: https://naturalselections.substack.com/p/informed-consent-in-the-land-of-psychiatric

How a Gemma model helped discover a new potential cancer therapy pathway: https://blog.google/technology/ai/google-gemma-ai-cancer-therapy-discovery

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Today we discuss the Camino de Santiago de Compostela—the history, the experience of hiking two routes, the physical and mental revelations that emerge.

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Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com/

Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)

Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

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Mentioned in this episode:

Camino – Primitivo route: https://stingynomads.com/camino-primitivo-stages

Camino – Finisterre route: https://stingynomads.com/camino-finisterre-muxia-stages

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Bret speaks with Nina Teicholz on the subject of seed oils.

Find Nina Teicholz on X at https://x.com/bigfatsurprise and on Substack at https://unsettledscience.substack.com.

Mentioned on this episode:

The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet by Nina Teicholz https://amzn.to/3WzaSYh (commission earned)

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Masa Chips: Delicious chips made with corn, salt, and beef tallow—nothing else—in loads of great flavors. Go to http://masachips.com/DarkHorse, use code DarkHorse, for 25% off.

Fresh Pressed Olive Oil Club: Scrumptious & freshly harvested. Go to http://www.GetFreshDarkHorse.com to get a bottle of the best olive oil you’ve ever had for $1 shipping.

Prima is offering 20% off their fantastic bars. Go to http://EatPrima.com/DarkHorse to get 20% off. Try Prima ancestral protein bars today!

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Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.

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Bret Weinstein speaks with Dr. Mark Cannon on the subject of the microbiome.

Dr. Mark L Cannon is a Professor Emeritus from Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University.

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Jolie: Beautiful shower heads that filter out the garbage without reducing water pressure. Go to http://jolieskinco.com/DarkHorse to get free shipping; free returns within 60 days.

Prima is offering 20% off their fantastic bars. Go to http://EatPrima.com/DarkHorse to get 20% off. Try Prima ancestral protein bars today!

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Join DarkHorse on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com

Check out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://www.darkhorsestore.org

Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.

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Bret Weinstein on confronting the new threat to free speech.

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Today we give a tribute to Charlie Kirk: who he was, how he engaged with people, and what we lost when we lost him. Kirk was a patriot, a Christian, a husband and a father, and believed in the humanity of all people. Then, for the living: regenerative agriculture, Polyface Farm, and the rejection of Big Ag in favor of real food and community.

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Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com/

Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)

Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

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Mentioned in this episode:

Robert Malone on the plot to get RFK Jr: https://www.malone.news/p/the-plot-to-get-rfk

Brownstone Institute and Spirits of America: https://brownstone.org/books/

Polyface Farm: https://polyfacefarms.com

Back to the Land: https://naturalselections.substack.com/p/back-to-the-land

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Today we discuss MAHA, vaccines, Covid, autism, and ostriches. Senator Ron Johnson held a hearing on the corruption of science, at which Jake Scott (MD), Toby Rogers (PhD), and lawyer Aaron Siri testified about vaccine safety testing and the relationship between vaccines and autism. The new MAHA Strategy report attributes poor diet, aggregation of environmental chemicals, lack of physical activity, chronic stress, and overmedicalization to the decline in children’s health. Meanwhile, people who have been fooled by the fear campaign celebrate getting their newest Covid boosters. And in Canada, ostriches are at risk of being killed because of a misunderstanding of immunity, but people are fighting back. The immune system that defends the body politic is discovering how to defeat the infection. The battle is over the public consciousness.

While we were livestreaming, news broke that Charlie Kirk was shot during an event in Utah and sadly passed away shortly after.

“Charlie Kirk was a beautiful person. He died engaging his foes honorably. I truly hope he’s right about the universe and is receiving his reward. I’m beyond heartbroken for his lovely family—we must take care of them. Let’s live up to his example.” – Bret Weinstein

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Our sponsors:

Masa Chips: Delicious chips made with corn, salt, and beef tallow—nothing else—in loads of great flavors. Go to http://masachips.com/DarkHorse, use code DarkHorse, for 25% off.

CrowdHealth: Pay for healthcare with crowdfunding instead of insurance. It’s way better. Use code DarkHorse at http://JoinCrowdHealth.com to get 1st 3 months for $99/month.

ARMRA: Colostrum is our first food, and can help restore your health and resilience as an adult. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.

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Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com

Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)

Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

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Mentioned in this episode:

Congressional hearing: https://www.hsgac.senate.gov/subcommittees/investigations/hearings/how-the-corruption-of-science-has-impacted-public-perception-and-policies-regarding-vaccines/

Childhood vaccines aren’t tested against placebo: https://naturalselections.substack.com/p/childhood-vaccines-arent-tested-against

MAHA Strategy report: https://www.whitehouse.gov/wp-content/uploads/2025/05/MAHA-Report-The-White-House.pdf

Covid boosters to show RFK: https://x.com/newstart_2024/status/1964562477716558123

Universal Ostrich Farm at Rebel News: https://www.rebelnews.com/breaking_b_c_ostriches_temporarily_saved_from_cfia_cull_by_interim_stay_order

Ostriches - Politico: https://www.politico.com/news/2025/07/15/why-rfk-jr-wants-canada-to-pardon-400-ostriches-00455360

Ostriches - Wall Street Journal: https://www.wsj.com/world/americas/universal-ostrich-farm-canada-jfk-oz-f6548a6a

Ostriches - WaPo: https://www.washingtonpost.com/world/2025/08/22/ostrich-bird-flu-canada-cull-rfk/

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Today we discuss RFK Jr. the CDC, autism and trans activism. Kennedy revealed this week that in 2002, the CDC destroyed data that showed that children who got the MMR vaccine before 36 months of age had far higher rates of autism than did those who get the vaccine later in life. An HHS report will soon be released that ties Tylenol use during pregnancy to autism—what does this tell us about past public health advice, safety and risk? How can we all become better at pattern recognition? Florida Surgeon General Joe Ladapo is moving away from vaccine mandates for all citizens, while the governors of the three West coast states are conflating “science” with “ideology” while pining for a Covid-era-style CDC. In trans land: comedy writer Graham Linehan was arrested for saying mean things on-line, while trans-activists are not arrested when they threaten to kick and punch those who don’t believe that men can become women. We explore the mental illness of trans-deluded people, and discuss Vivian Wilson, Elon Musk’s oldest son, who thinks he’s a girl.

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Timeline: Accelerate the clearing of damaged mitochondria to improve strength and endurance: Go to http://www.timeline.com/darkhorse and use code darkhorse for 10% off your order.

Manukora: the most flavorful, delicious, and nutritious honey you’ll ever have. Get $25 off your starter kit at http://www.Manukora.com/DarkHorse

Sundays: Dog food so tasty and healthy, even husbands swear by it. Go to http://www.sundaysfordogs.com/DARKHORSE to receive 35% off your first order.

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Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com

Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)

Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

(Thumbnail Andrew Harnik/Getty Images)

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Mentioned in this episode:

RFK before Congress: https://x.com/wallstreetapes/status/1964154838830502080

WSJ on Tylenol in pregnancy: https://www.wsj.com/health/healthcare/rfk-jr-hhs-to-link-autism-to-tylenol-use-in-pregnancy-and-folate-deficiencies-e3acbb4c

Western Health Alliance: https://apps.oregon.gov/oregon-newsroom/OR/GOV/Posts/Post/oregon-washington-and-california-form-western-health-alliance

Doyle on Linehan arrest in UnHerd: https://unherd.com/2025/09/the-shameful-arrest-of-graham-linehan/

Punch TERFs: https://x.com/babybeginner/status/1963504508509593772

Good genetics: https://x.com/hazelappleyard_/status/1963315154277593109

Vivian Wilson in NY Mag: https://www.thecut.com/article/vivian-wilson-elon-musk-daughter-2025-fall-fashion-issue-cover-story.html

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