Creatine Monohydrate: The Gold Standard Comparing Solubility and Bioavailability

• Many creatine supplement manufacturers claim their product is superior to creatine monohydrate (CrM) because it is more soluble.
• The sources state that solubility and bioavailability are not the same thing.
• Creatine monohydrate is nearly 100% bioavailable, meaning almost all of the CrM consumed is absorbed and used by the body.
• This high bioavailability is not affected by its solubility. Even if some CrM is undissolved in a glass of water, it will be absorbed by the body.
• Manufacturers often make misleading comparisons when discussing solubility. For example, one study compared the solubility of creatine hydrochloride (Cr-HCl) to CrM at very different pH levels, misrepresenting real-world solubility.
• The main benefit of increased solubility in alternative creatine forms is improved mixability; they dissolve more readily in water.
• This does not translate to increased absorption or effectiveness.
• No alternative form of creatine has been scientifically proven to be more bioavailable or effective than CrM.
• The sources recommend CrM because it is:
  • The most studied form of creatine and has a well-established safety and efficacy profile.
  • The most affordable form of creatine.
• The ability of a product to dissolve easily does not mean it is better absorbed and utilized by the body. When choosing a creatine supplement, scientific evidence should be prioritized over marketing claims.