Colorectal Cancer — An Interview with Dr John Strickler on Molecular Residual Disease Analysis (Companion Faculty Lecture)

Featuring a slide presentation and related discussion from Dr John Strickler, including the following topics:

• Defining molecular residual disease (MRD); tumor-informed and tumor-naïve methods for assessing (0:00)
• GALAXY and BESPOKE CRC studies of a tumor-informed MRD assay to identify patients with localized colorectal cancer who have an increased risk of recurrence and those who are likely to benefit from adjuvant chemotherapy (6:56)
• Sustained circulating tumor DNA (ctDNA) clearance and disease-free survival outcomes for patients with localized colorectal cancer (13:21)
• DYNAMIC study of a ctDNA-guided approach to adjuvant chemotherapy for patients with Stage II colorectal cancer (16:17)
• ctDNA positivity and radiographic evidence of colorectal cancer (18:48)
• ctDNA-guided approaches to escalating or de-escalating adjuvant chemotherapy for patients with localized colorectal cancer (21:24)
• Predictive role of ctDNA assay results in Stage III colon cancer treated with celecoxib; low-dose aspirin for patients with Stage II to III colorectal cancer with a PI3K pathway alteration (26:02)

CME information and select publications