On this episode we speak with Leah. Leah is a research assistant at Trialnet.org. but is also an MPH candidate in Epidemiology. Her drive comes from her family and friends. She's seen T1D up close and is passionate about early detection and making research feel human, accessible, and community powered. Her allyship speaks volumes!

At Trialnet they test family members of people living with T1D for risks of being diagnosed. They start testing as young as the age of 2 for T1D autoantibodies, all the way up to the

age of 40 if you have direct family members with T1D.

Trial Net contributed greatly to the treatment of Teplizomab, Tzield® (teplizumab) which is s a CD3-directed monoclonal antibody approved for delaying the onset of stage 3 type 1 diabetes in adults and children aged 8 years and older who have Stage 2 type 1 diabetes. It works by attaching to proteins on immune cells, helping to protect the insulin-producing cells in the pancreas from being attacked. Tzield was approved in the US in November 2022 and is the first

disease-modifying therapy for autoimmune type 1 diabetes.

For more detailed information, you can refer to the official Tzield website or the FDA label

During our conversation we speak about the misdiagnosis of adults with diabetes and the challenges in care because of the proper education and tools not being given to them. At Trial Net, instead of continuously monitoring a finger pricks, that we know the child hates, and parents hate as well, if you live with T1Dyou can just have this simple lab drawn to determine their future risks. It's a win-win for everyone! It's a simple blood withdrawal; it's not a lot. It's no more than a typical blood withdrawal from a lab. If they can get this done, you will have immediate direct knowledge of what to look for moving forward. Is my child going to have it or if

they're not? Right.

Visit Trialnet.org to get screened. It's 100% Free.

On this episode we get to hear from Marlaina Goedel. 14 months ago, Marlaina was fully, functionally cured of living with Type 1 diabetes. The procedure was the first of it's kind in the world, performed by Dr. Pior Witkowski at UC Med. With this process they inserted donor islet cells into Marlaina's liver and used the new monoclonal antibody Tegoprubart as the main antirejection infusion.

After 25 years of living with Type 1 and having dealt with too many hospitals stays to recall and far too many times having to be rescued by her loved ones, including her daughter she no longer lives with T1D.

During this episode Marlaina shares answers to every question that you could think of answering. And as Marlaina mentioned, "We did it!" She took this step for us all, not because only her own experience with diabetes.

Marlaina was a pure gem to record with and her story is story of hope for everyone. To-date there have been 12 people in the clinical trial after Marlaina's successful transplant. So far, everyone is on schedule to be insulin dependent like Marlaina (6 in total during the second phase already are).

You can follow Marlaina on Instagram @ilovemiley94

Find her on Facebook at Marlaina Goedel

Donate to support Marlaina continue this new life

On this episode, we hear from Jisel. Jisel has been living with Type 1 Diabetes for 22 years, having been diagnosed near the end of her sophomore year of high school at 15 in 2003. Jisel is a wife, mom of two, and a self-proclaimed Serial Volunteer! Whether it's school events, work-related, or with her people, in the T1D community, you can find Jisel always lending a hand, foot, time, and dedication to the communities she serves.

In this episode, Jisel shares everything else, plus diabetes, including how challenging it was for a 15-year-old young girl learning to advocate for herself as a newly diagnosed Type 1, and as an adult throughout her pregnancies.

Jisel is not only someone you should get to know but she's someone that is making things happen in the diabetes space!

Follow Jisel @jisel.p_andt1d