🎙️ Understanding Cyclodextrin Safety – Myths & Facts

Cyclodextrins play a crucial role in pharmaceuticals, improving drug solubility and stability. But how do they interact with the human body, and what do we really know about their safety? In this episode, we explore:

🔹 How dosage and route of administration impact cyclodextrin safety
🔹 Key findings on oral, nasal, dermal, ocular, and intravenous applications
🔹 Considerations for patients with kidney impairment and young children
🔹 Insights from toxicology studies – what’s known, what’s uncertain

Join us as we break down the science behind cyclodextrins, addressing both their benefits and safety concerns in a balanced discussion. Tune in for expert insights!

🎙️ New Episode Alert – Carbohydrate Chronicles, S2E2
In this episode of Carbohydrate Chronicles, we’re diving deep into the world of cyclodextrins (CDs) and their fascinating potential in biological drug formulations. From stabilizing delicate protein therapeutics to boosting vaccine efficacy and breaking new ground in gene therapy, CDs are proving to be far more than just sugar rings. We unpack how their unique structure allows for molecular encapsulation—enhancing solubility, stability, and delivery while minimizing side effects. Whether you're in drug development or just love cutting-edge biotech, this masterclass offers a fresh look at how CDs are redefining the biologics space.

We also explore real-world applications and challenges: Why haven't CD-based monoclonal antibodies reached the market yet? How do CDs stack up against polysorbates, and what makes them ideal cryoprotectants in vaccines? Plus, get a sneak peek at CarboHyde’s pioneering research into CD-based gene delivery systems that could rival lipid nanoparticles in efficiency and safety. Tune in to discover how these versatile molecules are quietly reshaping the future of pharmaceutical formulations.

Podcast Summary: Cyclodextrins – More Than Just Pharma

In this episode, we explore the surprising versatility of cyclodextrins—natural molecules that improve solubility, stability, and delivery of other substances.

They're not just for medicine! Cyclodextrins are used in:

• Supplements: Boosting ingredients like vitamin D and curcumin.

• Food: Enhancing texture, shelf life, and reducing cholesterol.

• Cosmetics: Stabilizing and releasing active ingredients and fragrances.

• Agriculture & Textiles: Improving delivery of nutrients and embedding scents in fabrics.

• Energy & Environment: From better batteries to filtering pollutants.

• Even Space Missions: Helping detect molecules on Mars!

💡 Bottom line: Cyclodextrins are tiny, powerful tools shaping many industries—with endless potential ahead.