Can't Get Off Antidepressants? Ask for These Lab Tests

Why do so many people with depression struggle to stop their antidepressants? What if the answer isn't about willpower — but about missing nutrients your brain needs to function?

Dr. James Greenblatt has spent 30 years in inpatient psychiatry. He watched patients go from one medication to two, then three, then five. Suicide rates kept climbing. And he started asking: What if the brain is simply missing what it needs?

His new book Finally Hopeful explores the biological causes of depression most doctors never test for.

Get the full episode breakdown at Biology of Trauma® Podcast - Episode 156: Can't Get Off Antidepressants? Ask for These Lab Tests

In This Episode You'll Learn:

• [04:09] Why Dr. Greenblatt wrote Finally Hopeful after 30 years in psychiatry
• [12:50] Vitamin D as the foundation: Why nothing else works without it — not meds, not therapy
• [14:35] How vitamin D deficiency affects serotonin production in the brain
• [12:50] Dr. Aimie's personal story: vitamin D levels of 12, then only 20 with supplementation
• [17:06] Why vitamin D deficiency is one of the most common factors in people who can't stop antidepressants
• [18:48] The gut-serotonin connection: 90-95% of serotonin is made in the gut
• [21:00] The building blocks your brain needs: iron, B12, folate, zinc, magnesium
• [24:57] Brain inflammation and its connection to suicide risk
• [26:14] Why sleep deprivation creates inflammatory markers within hours
• [32:07] The simple labs to ask your doctor about — and why testing is the only path forward

Resources/Guides:

• Free Guide: Top 3 Biochemical Imbalances That Affect Mood - a starting point for understanding the most common nutrient imbalances connected to depression
• The Biology of Trauma book - Available now everywhere books are sold. Get your copy
• Foundational Journey - The 6-week program to create inner safety and shift your nervous system. Build the foundation that allows your body to actually use the nutrients and support you give it.
• Dr. James Greenblatt - Get a copy of the Finally Hopeful book and find more resources at https://www.jamesgreenblattmd.com/

Related Podcast Episodes:

• Episode 41: Solutions for Low Serotonin and GABA in Trauma with Trudy Scott
• Episode 101: Brain Inflammation: Addressing The Overlooked Gatekeeper To Trauma Release with Dr. Austin Perlmutter