CHAMPION‑AF Decoded: Watchman Flex vs DOACs

In this episode of ICChat, Dr. Ashish Pershad MD MS reviews and critiques the CHAMPION‑AF trial comparing Watchman Flex left atrial appendage occlusion to DOACs for atrial fibrillation. He explains the trial design, endpoints, and statistical choices, and contrasts the published results with real‑world implications.

The episode highlights concerns about non‑inferiority margins, excluded procedural bleeding, lower than expected event rates, and the importance of shared decision making when considering LAAO versus lifelong anticoagulation.