Beyond Needles: Benefits and Insights Into Intranasal Vaccines

In this episode, host Dr Sean Stevens is joined by Dr Paul Effler, Senior Medical Advisor at the WA Department of Health and Adjunct Dr at the University of Western Australia. Dr Effler is an experienced public health physician with extensive expertise in vaccine safety surveillance and has been a longstanding member of the WHO Global Advisory Committee for Vaccine Safety.

They explore the use of intranasal vaccines for influenza and COVID-19, which are now available in Australia. Dr Effler explains the mechanistic advantages of intranasal vaccines compared to traditional intramuscular injections, highlighting their ability to create mucosal immunity at the site where respiratory pathogens enter the body. Offering the dual possibility of preventing both clinical infection and onward transmission which is a key public health benefit.

Practical aspects of administering intranasal vaccines in general practice are discussed, including ease of use, absence of sharps and associated risks, and specific technique considerations.

Looking ahead, they also covered potential future developments in intranasal immunisation, including vaccines for RSV and pertussis, and the promise of platforms that do not rely on live attenuated virus. Dr Effler describes emerging models of self-administration and the possible implications for increasing vaccine uptake, while reaffirming the ongoing role of GPs in supporting safe and effective immunisation.

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