Here I describe evidence that brain aging can be slowed by lifestyle choices that include exercise, moderation in energy intake, and consumption of plant-based diets.

LINKS

https://pmc.ncbi.nlm.nih.gov/articles/PMC5913738/pdf/nihms958771.pdf

https://www.cell.com/action/showPdf?pii=S1550-4131%2823%2900473-4

In this episode I talk with Case Western Reserve University Professor Andrew Pieper about how it might be possible to restore neuroplasticity and cognition in Alzheimer's disease. The conversation focuses on a recently published study from his laboratory which shows that a chemical called P7C3-A20 that restores energy balance in brain cells can reverse brain pathology and restore cognitive function in a mouse model of Alzheimer's disease.

LINKS

Pieper laboratory:

https://www.harringtondiscovery.org/about/harrington-investigators/andrew-pieper-lab

Article discussed in this podcast:

https://www.cell.com/action/showPdf?pii=S2666-3791%2825%2900608-1

In this lecture I describe how changes occurring in the brain during normal aging set contribute to the pathogenesis of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. Cellular and molecular hallmarks of aging predispose brain cells to neurodegenerative orders with environmental and genetic factors determining if and when the disease manifests.

LINKS:

Review articles:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3710114/pdf/nihms288391.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC7948516/pdf/nihms-1624328.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC9242841/pdf/nihms-1685119.pdf