AUTM on the Air Podcast Por AUTM arte de portada

AUTM on the Air

AUTM on the Air

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AUTM on the AIR is the weekly podcast that brings you conversations about the impact of research commercialization and the people who make it happen. Join us for interviews with patent and licensing professionals, innovators, entrepreneurs, and tech transfer leaders on the issues and trends that matter most.

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Episodios
  • A Father's Mission: How Danyelza Became a Life-Saving Therapy for Pediatric Neuroblastoma with Dr. Nai-Kong Cheung, Dr. Yashodhara Dash & Dr. Imke Ehlers-Surur

    A Father's Mission: How Danyelza Became a Life-Saving Therapy for Pediatric Neuroblastoma with Dr. Nai-Kong Cheung, Dr. Yashodhara Dash & Dr. Imke Ehlers-Surur
    Mar 25 2026
    Sometimes the most powerful innovations come from the most personal places. This episode tells the extraordinary story of Danyelza (naxitamab), a life-saving immunotherapy for children with neuroblastoma, and how it earned a finalist spot in the AUTM Better World Project.What makes this story truly remarkable isn't just the science, although that's impressive enough. It's the unlikely partnership between a researcher who refused to give up, a tech transfer team that believed in an "ultra-orphan" drug when no one else would, and a father who turned his desperation into determination by founding a company to bring this therapy to other children facing the same devastating diagnosis as his daughter.Joining me are three key figures from Memorial Sloan Kettering Cancer Center who shepherded this breakthrough from lab bench to bedside: Dr. Nai-Kong Cheung, the Enid A. Haupt Chair in Pediatric Oncology and a world-renowned expert in antibody-based therapies for childhood cancers; Dr. Yashodhara Dash, Vice President of Entrepreneurship & Commercialization at MSK; and Dr. Imke Ehlers-Surur, Director of Technology Development & Licensing, who negotiated one of the most unconventional licensing deals in tech transfer.We discuss the 25-year journey from early mouse antibodies to FDA approval, why pharma companies initially passed on this technology, how regulatory designations like the rare pediatric disease priority review voucher changed the business case, and what happened when MSK had to decide which patients would receive limited drug supplies a moment Dr. Cheung compares to Schindler's List.Disclosure: MSK and Dr. Cheung have financial interests in Danyelza.In This Episode:[03:07] Dr. Cheung explains neuroblastoma is a devastating childhood cancer that spreads to bone, bone marrow, and other organs, making it one of the most difficult pediatric cancers to treat.[04:31] The "aha moment" came in the mid-1990s with antibody 3F8, when the team saw how these antibodies could light up tumors and eliminate metastatic disease.[07:00] The early mouse antibody got rejected by the body, so the team used protein engineering to create a humanized version that could arm the immune system without rejection.[08:14] Funding was one of the toughest challenges working with small budgets meant relying heavily on internal grants and parent groups like the Band of Parents.[09:31] Dr. Dash describes the commercial landscape as a "hard sell". It was an ultra-orphan market, and companies wanted small molecules instead of antibodies.[10:22] Persistence and entrepreneurial mindset kept the project going internally, applying for FDA designations and advancing the technology before finding the right partner.[11:01] Dr. Ehlers reveals Y-mAbs Therapeutics was founded by Thomas Gadd, the father of one of Dr. Cheung's patients, who built a company when other paths stalled.[12:07] Working with a founder who had unparalleled motivation but limited drug development experience meant MSK developed a forward-looking commercialization strategy.[14:28] The biggest difference in negotiating with a patient-family founder versus traditional VCs was making sure both sides were speaking the same language.[17:34] While MSK's Technology Development Fund provided some gap funding, the real story was philanthropic support from groups like the Band of Parents.[18:42] The conversation turns to FDA accelerated approval in November 2020, after running out of drugs and having to decide which patients would benefit a moment compared to Schindler's List.[21:12] To avoid conflicts of interest when helping form Y-mAbs in 2015, stepping out of the clinic completely became necessary to focus on research full time.[24:19] The regulatory designations were "transformative" orphan drugs given seven years of exclusivity, and the rare pediatric disease designation came with a priority review voucher worth $80-300 million.[27:18] Without these regulatory incentives, the startup may not have been fundable at all, though Thomas Gadd is noted as a "force of nature."[28:18] Y-mAbs' acquisition by CERB Pharmaceuticals means proceeds will flow back to MSK to fund future cancer research, a typical life cycle for early stage technologies.[29:41] Finding a drug or cure for a child so they can reach their full potential is described as priceless, with reflections on the anguish parents face.[30:58] A powerful story about a physician father whose daughter responded to the antibody but ultimately died from graft versus host disease, an experience that drives the mission.[34:05] When there's a convergence of mission and purpose with many people participating, that flame will continue to burn and inspire other tech transfer offices.[35:34] The conversation concludes with emphasis on the importance of philanthropy, the power of parents, and finding a mission-driven partner to achieve FDA approval.Resources: AUTMMemorial Sloan Kettering Cancer CenterThe Nai-Kong Cheung LabDr. Nai-Kong ...
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    38 m
  • Tokenizing the Future: How Brilliance Is Creating a New Model for IP Ownership and Investment with Chris Hack and Geoffrey Smith

    Tokenizing the Future: How Brilliance Is Creating a New Model for IP Ownership and Investment with Chris Hack and Geoffrey Smith
    Mar 18 2026
    If you've ever thought that intellectual property was just for lawyers, patent professionals, and the occasional venture capitalist, today's episode might change your mind. We're talking about what it would look like if anyone, your neighbor, your parents, maybe even a seven-year-old with a wallet could find, understand, and invest in the technologies shaping our future. It's a big idea, and our guests are actively building the infrastructure to make it real.Chris Hack and Geoffrey Smith are the co-founders of Brilliance, a company working at the intersection of AI, blockchain, and decentralized finance to make intellectual property more accessible and investable. They're building tools that help non-specialists navigate patent landscapes using plain language search, connecting problem-solvers with the right opportunities, and experimenting with tokenization as a way to open royalty stream investing to a much broader audience than has ever had access before.In this conversation, we dig into what it actually means to democratize IP, how AI is changing the discovery and translation of patents for people outside the profession, and what role blockchain and smart contracts could realistically play in the future of licensing and royalty management. We also talk about the guardrails that need to exist, the misconceptions worth clearing up, and where Chris and Geoffrey see the biggest opportunities for tech transfer offices to dip their toes in without taking on a lot of risk.In This Episode:[02:28] Chris explains that democratizing IP is less about what it is and more about who can access it everyday people, not just specialists.[02:30] The biggest barriers to IP participation are readability, discoverability, and the high cost of creation, all of which technology can help address.[03:49] Geoffrey adds that beyond discovery and translation friction, there's a matching problem: universities want partners, companies want solutions, and no one has solved the bridge between them.[03:50] Brilliance built AI tools not for patent professionals, but for investors and entrepreneurs who need a low-friction first pass at understanding what a patent covers and why it matters.[05:13] The tools are not patent drafting tools, they're designed to expand the footprint of who engages with IP in the first place.[05:48] Chris and Geoffrey share their vision of making IP as conversational and familiar as real estate, starting with the people closest to us.[07:57] Tech transfer offices can list IP on Brilliance's repository for free, feeding their AI model and getting exposure to a new class of potential investors.[09:55] The conversation turns to tokenization and why NFTs in this context have nothing to do with digital art and everything to do with creating an immutable ledger for royalty contracts.[10:21] Chris breaks down how NFTs function in their prototype marketplace as pointers or receipts, not the underlying contracts themselves.[12:49] Brilliance's current model involves acquiring royalty streams, syndicating the funding, and owning the stream with a vision to move those transactions fully on-chain over time.[13:50] Smart contracts in this context aren't legal agreements, they're programmable rules that govern how a token behaves on the blockchain and direct payments to whoever holds it.[15:39] Blockchain explorers could eventually give municipalities and governments real-time visibility into where innovation is happening and where to direct funding.[16:34] The most common concerns Brilliance hears from institutions involve regulatory uncertainty and security, but Chris and Geoffrey treat those as design guidelines, not dealbreakers.[18:49] Compliance and governance aren't obstacles; they're the blueprint for building the right product, including AML and KYC requirements for the next marketplace iteration.[19:06] The team is watching the Genius Act and Clarity Act closely, hoping clearer federal guidelines will let them move with more confidence.[20:08] Brilliance focuses on non-dilutive funding by purchasing the economic interest in a royalty stream while leaving the underlying IP assets intact.[22:00] Guardrails for tokenized IP investment need to address regulatory compliance, asset vetting, buyer and seller transparency, and clear valuation frameworks.[24:00] For tech transfer offices wanting a low-risk entry point, the IP repository is free, requires minimal effort, and immediately connects listings to active investors using AI search.[24:30] The Connect platform matches problem-havers with problem-solvers using embedded AI, and was built specifically to solve the sponsored research visibility problem.[25:30] Chris addresses common misconceptions: NFTs are not speculative assets, smart contracts are not legal contracts, and blockchain does not require cryptocurrency speculation.[26:49] Geoffrey's son asked how to invest in robots and that question became their clearest articulation of what success looks like in five...
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    34 m
  • The Industry Side of the Table: How Samsung Evaluates University Partnerships with David Chang

    The Industry Side of the Table: How Samsung Evaluates University Partnerships with David Chang
    Mar 11 2026

    If you've ever wondered what's actually going on inside a company's head when a university comes knocking with a new technology, today's episode is for you. We're getting into the real mechanics of university-industry partnerships and what makes them work, what slows them down, and where the biggest opportunities are being left on the table.

    My guest today has lived this from just about every angle imaginable. He started his career in Ecuador, where he built the country's first university tech transfer office essentially from scratch. He then co-founded an ed-tech startup that turned profitable in its first year, led digital innovation licensing at Duke University, and now sits on the industry side at Samsung Research America, where he manages university collaboration programs and serves as a bridge between academic research and one of the world's largest tech companies.

    In this conversation, we get into what Samsung actually looks for when a university brings an opportunity forward, how they think about technology at different stages of readiness, and why the human factor in these relationships matters more than most people realize. We also talk about how fast-moving fields like AI are changing the rules of the game for tech transfer professionals, and he shares some really practical advice on how to position technologies so companies lean in rather than walk away.


    In This Episode:

    [03:12] David Chang shares how curiosity and a belief in innovation as an engine for economic development shaped his global career in tech transfer.

    [03:58] His path spans building Ecuador’s first tech transfer office, founding a startup, working at Duke, and now leading university partnerships at Samsung.

    [04:41] Early work in Ecuador showed how innovation ecosystems develop slowly through trust and incremental collaboration.

    [05:36] In emerging markets, university partnerships often begin with student projects before growing into research and commercialization efforts.

    [06:44] David explains how seeing both the university and corporate sides of tech transfer reshaped his perspective.

    [08:09] Relationships between tech transfer offices and industry partners often drive successful collaborations more than databases or programs.

    [09:47] Industry timelines can be tight, and lengthy contract edits can create friction in university–industry partnerships.

    [11:13] At Samsung’s LeapU program, three factors help advance a university technology: differentiation, clear milestones, and strategic fit.

    [12:08] Demonstrations that spark an internal “aha moment” can help companies rally support for a new technology.

    [13:27] Samsung evaluates proposals through a balance of technology push and market demand.

    [14:16] The company organizes partnerships by technology readiness through the START, LeapU, and LeapS programs.

    [14:58] START accepts early research ideas, while LeapU and LeapS rely on trusted relationships and invitations.

    [15:43] Strong university partners often begin with deep expertise in a specific research area.

    [16:29] Tech transfer offices add value by mentoring researchers on IP strategy and identifying entrepreneurial investigators.

    [17:52] Emerging technologies like AI and robotics are pushing companies toward new collaboration models.

    [18:41] Development speed matters in AI, where innovations can become obsolete within a short time.

    [19:36] Platform technologies with modular components are often easier for companies to adopt than standalone inventions.

    [21:18] Cultural factors such as flexibility and ongoing dialogue often distinguish the best university partners.

    [22:44] Researchers interested in collaborating with Samsung should highlight their research background and concrete collaboration ideas.

    [24:03] Combining technical depth with a strong business case can help tech transfer professionals position inventions more effectively.

    [25:32] Industry conferences like AUTM provide valuable opportunities to build long-term collaboration networks.

    [26:18] Reflecting on his career, David notes how working on both sides of tech transfer deepened his understanding of how innovation moves to market.


    Resources:

    AUTM

    Samsung Research America

    START

    LEAP-U

    LEAP-S
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    27 m
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