A Breakthrough in Studying Diseases of the Brain

Chronic traumatic encephalopathy, or CTE, is a neurodegenerative disease linked to repeated head injuries. It has been found in professional athletes, soldiers, and others who have experienced years of those traumas. New research from Harvard Griffin GSAS alumni Chanthia Ma and Guanlan Dong may help us better understand this condition. Their study looks at the smallest units of brain biology—individual neurons—and finds surprising clues written in the DNA itself. Using single-cell genome sequencing, they discovered that neurons in people with CTE carry distinctive patterns of genetic damage—patterns that may overlap with those seen in Alzheimer’s disease. In this episode of Colloquy, Ma discusses how her work not only sheds light on how brain trauma leads to long-term decline but also hints at possible shared mechanisms across different neurodegenerative conditions.