#524: 38 things Python developers should learn in 2025

Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB and Arrow, PyScript at the edge, plus MCP for sane AI workflows. Expect practical wins and migration paths. No buzzword bingo, just what pays off in real apps. Join me along with Peter Wang and Calvin Hendrix-Parker for a fun, fast-moving conversation. Episode sponsors Seer: AI Debugging, Code TALKPYTHON Agntcy Talk Python Courses Links from the show Calvin Hendryx-Parker: github.com/calvinhp Peter on BSky: @wang.social Free-Threaded Wheels: hugovk.github.io Tilt: tilt.dev The Five Demons of Python Packaging That Fuel Our ...: youtube.com Talos Linux: talos.dev Docker: Accelerated Container Application Development: docker.com Scaf - Six Feet Up: sixfeetup.com BeeWare: beeware.org PyScript: pyscript.net Cursor: The best way to code with AI: cursor.com Cline - AI Coding, Open Source and Uncompromised: cline.bot Watch this episode on YouTube: youtube.com Episode #524 deep-dive: talkpython.fm/524 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[e-mail] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[e-mail] Michael on X.com: @mkennedy