The 49ers have endured a rash of injuries to star players to start their season, and that list grew emphatically by one more player Monday morning following the news that defensive end Nick Bosa reportedly will have to undergo season-ending surgery to repair a torn ACL. On this emergency episode of '49ers Talk,' Matt Maiocco is joined by Carlos Ramirez to discuss the fallout from this massive injury. How will the 49ers proceed, who will step-up in place of the former NFL Defensive Player of the Year, can San Francisco bring in reinforcements externally and will that change their current strategy of roster-construction? Matt and Carlos tackle these tough questions as the undefeated 49ers must find answers just three weeks into the NFL regular season.

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(1:00) Third time Nick Bosa has sustained a torn ACL
(2:30) Losing Bosa is not just a loss on the field, but also with his leadership
(5:00) Will the 49ers dip into the trade market to replace Bosa?
(10:00) Will the 49ers pivot from their current strategy of building depth with youth?
(12:00) This situation is similar to the Loins losing Aidan Hutchinson last season

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The 49ers' home opener against the Arizona Cardinals brought plenty of twists and turns as San Francisco emerged victorious to maintain its undefeated start with a thrilling 16-15 win. Kicker Eddy Piñeiro's game-winning field goal and Mac Jones' clinical two-minute drive got the 49ers over the hump in a gutsy win, improving San Francisco to 3-0 in the 2025 season. The win didn't come without its costs as star defensive end Nick Bosa exited the game with an apparent knee injury. Matt Maiocco and Jennifer Lee Chan break down the 49ers' courageous victory, Bosa's injury and how San Francisco's alleged weakness in depth has turned into their strength as they now sit atop the NFC West standings.

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(1:00) Uncommon scoreline, but 49ers are making these kinds of win common
(3:00) Nick Bosa injury update
(6:00) Eddy Piñeiro delivers in the clutch
(10:00) Mac Jones seems to rise to the occasion
(12:00) 49ers' defense is putting the team on their back
(30:00) Robert Saleh has been the key to unlocking 49ers' defense

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Matt Maiocco speaks with 49ers coach Kyle Shanahan about their Week 3 matchup vs. the Arizona Cardinals and discuss how Luke Farrell and Jake Tonges have stepped up after injuries to George Kittle and Kyle Juszczyk. Also Greg Papa joins Matt to breaks down how 49ers’ improved speed on defense can contain Kyler Murray.

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(6:19) Kyle Shanahan dissects Mac Jones’ Week 2 performance vs. Saints
(10:08) Shanahan shares how Christian McCaffrey is 49ers’ consistent weapon
(12:10) Shanahan impressed with how Luke Farrell and Jake Tonges have stepped up
(14:14) Shanahan discusses Mykel Williams’ versatility in pass game and third down
(18:12) What growth has Shanahan seen in Robert Saleh after return?
(25:10) Greg Papa shares key matchups vs. Arizona
(29:12) Matt and Greg discuss 49ers’ banged-up offensive line
(32:44) Can 49ers’ improved speed on defense contain Kyler Murray?

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