41. Unlocking the Gut-Brain Connection with Dr. Vincent Pedre

We talk a lot about fitness, metabolism, and hormones on this show — but if your gut's not right, none of it works properly.

In this week's episode of Healthy AF, I sit down with Dr. Vincent Pedre, board-certified internist, functional medicine pioneer, and author of the bestselling book Happy Gut. Dr. Pedre has spent over two decades helping people repair their gut health, rebalance their microbiome, and understand how the gut affects every system in the body — from mood and memory to metabolism and sleep.

We dive deep into the gut-brain connection — how your gut literally talks to your brain through the vagus nerve, and why 95% of serotonin is produced in your gut (not your head). Dr. Pedre breaks down how stress, alcohol, and common over-the-counter meds disrupt digestion and even rewire your mood.

He also explains how gut dysfunction can lead to metabolic disease, chronic fatigue, and hormone imbalance, and what to do about it. From fermented foods and fiber to liver detox and real-world habits, this conversation connects the dots between gut health, mental health, and longevity.

We also talk about Dr. Pedre's new product, Happy Gut Coffee — a low-acid, toxin-free roast tested for mold, glyphosate, and pesticides — and why something as simple as your morning coffee might be holding back your health goals.

If you've ever struggled with brain fog, bloating, or burnout — this episode will help you understand why your gut might be the first place to start healing.

💡 Key Takeaways

• The gut microbiome influences mood, metabolism, and immune health.
• 95% of serotonin is made in the gut, not the brain.
• The vagus nerve connects your emotions, digestion, and sleep quality.
• Alcohol, NSAIDs, and stress are major microbiome disruptors.
• Fermented foods lower inflammation and improve brain health.
• Gut inflammation can lead to insulin resistance and metabolic disease.
• Fiber + fermented foods = powerful combination for reducing stress and inflammation.
• Regular, effortless bowel movements are essential for detox and hormone balance.
• Your liver and gut work together to remove toxins and regulate estrogen.
• Even your coffee can support (or sabotage) your gut health.

Episode Timestamps:

• 00:00 — Intro: Meet Dr. Vincent Pedre, gut health and functional medicine expert
• 03:00 — The missing piece: what doctors never learned about the gut microbiome
• 06:00 — The gut-brain connection explained
• 08:00 — How serotonin is made in the gut (and why it matters)
• 12:00 — Stress, the vagus nerve, and sleep quality
• 15:00 — Alcohol: short-term calm, long-term chaos
• 18:00 — Why mindset and emotion drive gut-related habits
• 22:00 — Stomach acid, digestion, and feeling full
• 27:00 — Fermented foods vs. fiber: which one lowers inflammation
• 29:00 — The psychobiotic diet and its effect on stress levels
• 33:00 — Endotoxin, leaky gut, and how inflammation starts
• 37:00 — Gut health and detoxification: liver, estrogen, and weight loss
• 40:00 — Why bowel regularity matters for hormones
• 43:00 — Creating Happy Gut Coffee: how Dr. Pedre cleaned up caffeine
• 47:00 — Why your coffee could be sabotaging your health goals
• 49:00 — Where to learn more and connect with Dr. Pedre

Connect with Zane Griggs:

• 🧠 Free Plan: free40plan.com
• 📲 Instagram: @zanegriggsfitness
• 🌐 Website: zanegriggs.com

Guest Links:

• https://pedremd.com
• https://happygutlife.com
• IG: @‌drpedre