#283 - Brain health explained: Insulin resistance, biomarkers, and Alzheimer’s risk | Dr. David Perlmutter & Mike Haney
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#283 - Brain health explained: Insulin resistance, biomarkers, and Alzheimer’s risk | Dr. David Perlmutter & Mike Haney
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Alzheimer’s and dementia aren’t just a matter of age or genetics. Increasing evidence shows that metabolic health—particularly insulin resistance—plays a key role in cognitive decline.
In this episode of A Whole New Level, neurologist and bestselling author Dr. David Perlmutter joins Mike Haney to explore the links between brain health and metabolism. They discuss the role of insulin resistance and inflammation in Alzheimer’s disease, the biomarkers that can reveal risk decades before symptoms, and how lifestyle interventions can dramatically change your trajectory.
Topics include:
- Key biomarkers for assessing brain health: fasting insulin, A1C, homocysteine
- Why targeting inflammation may matter more than targeting amyloid plaques
- The promise and limitations of GLP-1 medications for dementia and Parkinson’s
- Practical steps you can take now to protect long-term cognitive function
Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl
🎙 What Dr. David Perlmutter & Mike Haney discuss:
4:12 — Why Alzheimer’s is now called “Type 3 diabetes”
9:45 — The role of inflammation in brain health
15:22 — Biomarkers that predict dementia risk decades early
22:31 — Why mainstream Alzheimer’s drugs fall short
29:17 — GLP-1s and brain health
36:44 — Lifestyle changes vs. pharmaceuticals
44:19 — Why homocysteine matters
53:02 — Sleep, circadian rhythm, and brain resilience
1:02:38 — Early warning signs you shouldn’t ignore
1:15:07 — The hopeful message
Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.
Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.
🔗 Helpful links:
Watch the conversation: https://youtu.be/MV_9nyAN1Vk
Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1
📲 Connect:
Dr. David Perlmutter on X: @DavidPerlmutter
David Perlmutter, MD: https://drperlmutter.com/