#171 Two Science-Backed Strategies to Slow Aging

In this episode of Hart2Heart, host Dr. Mike Hart dissects the science of aging and how to slow it down by optimizing cellular health. He breaks down two key strategies: autophagy and senolysis. Autophagy, the body’s process of clearing out damaged cells, can be activated through fasting, cold plunges, sauna therapy, and high-intensity interval training. Dr. Hart also shares key supplements that promote autophagy. Senolysis focuses on eliminating ‘zombie’ cells, damaged cells, that contribute to aging and inflammation. Dr. Hart explains how this process can be enhanced through similar lifestyle strategies and specific supplements like fisetin and quercetin.

Show Notes:

• (0:00) Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

• (0:15) Dr. Hart introduces today’s topic - How to slow againg

• (0:45) Understanding aging at the cellular level

• (2:30) Strategy #1: Autophagy - The body’s self cleaning process

• (4:00) Optimal benefits of fasting

• (5:00) Behavioral factors to induce autophagy

• (7:00) Benefits of ketosis for anti-aging

• (9:15) Supplements to induce autophagy

• (21:30) Strategy #2: Senolysis - eliminating “zombie” cells

• (22:45) Behavioral factors for Senolysis

• (25:00) Benefits of sauna for aging

• (26:30) Benefits to cycle to clear our zombie cells

• (30:00) Closing thoughts

Supplements/Resources Mentioned:

Where to buy Supplements - iHerb

Spermidine - Mimics fasting effects and promotes cellular regeneration.

Berberine - Helps regulate blood sugar and may mimic Metformin’s longevity benefits.

Quercetin - An antioxidant that supports immune health and autophagy.

Resveratrol - Found in red wine, linked to longevity and anti-aging benefits.

Curcumin - Anti-inflammatory compound from turmeric; supports brain and joint health.

EGCG (from Green Tea) - May boost autophagy but could impact testosterone levels.

Boron - Reduces inflammation and increases free testosterone by lowering SHBG.

Fisetin - A flavonoid that helps remove senescent (zombie) cells and reduces inflammation.

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Dr. Mike Hart is a Cannabis Physician and Lifestyle Strategist. In April 2014, Dr. Hart became the first physician in London, Ontario to open a cannabis clinic. While Dr. Hart continues to treat patients at his clinic, his primary focus has shifted to correcting the medical cannabis educational gap that exists in the medical community.

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