THE NEW FUNCTIONAL MEDICINE NEPHROLOGY™

Root-Cause Kidney Disease Reversal Using the TOBIN™ Framework, Orthomolecular Science, and Systems Biology

THE NEW FUNCTIONAL MEDICINE NEPHROLOGY™
Root-Cause Kidney Disease Reversal Using the TOBIN™ Framework, Orthomolecular Science, and Systems Biology

Benoît Tano, MD, PhD

Kidney failure is not inevitable. Dialysis is not a cure. Transplantation is not the end of the story.

For decades, modern nephrology has treated kidney disease as progressive, irreversible, and ultimately fatal—managed rather than cured. Millions of patients worldwide are told the same story: “Your kidney function will continue to decline. Prepare for dialysis or transplant.”

This book proves that narrative is incomplete—and fundamentally flawed.

A REVOLUTIONARY PARADIGM SHIFT IN NEPHROLOGY

The New Functional Medicine Nephrology™ introduces a root-cause, systems-biology approach to kidney disease that goes far beyond symptom suppression and late-stage interventions. Drawing on cutting-edge molecular biology, environmental medicine, orthomolecular science, immunology, endocrinology, and redox biology, Dr. Benoît Tano presents a new, unified framework for understanding—and reversing—kidney disease in the 21st century.

At the center of this transformation is the TOBIN™ Framework:

• Toxin Overload

• Oxidative Stress

• Biological & Hormonal Imbalance

• Infections (chronic, latent, and immune-triggering)

• Nutrient Deficiencies

Together, these five upstream drivers explain why kidney disease has exploded globally since the 1990s—and why conventional nephrology has failed to stop it.

INSIDE THIS BOOK YOU WILL DISCOVER:

• The true root causes of chronic kidney disease, acute kidney injury, and renal failure

• Why creatinine and eGFR are late, misleading markers

• How environmental toxins, pharmaceuticals, heavy metals, PFAS, pesticides, and mycotoxins silently destroy kidneys

• The mitochondrial and oxidative stress mechanisms driving nephron failure

• The hidden hormonal drivers of kidney disease (insulin, aldosterone, cortisol, estrogen, thyroid, vitamin D, PTH, FGF-23)

• How chronic infections and immune dysregulation damage the kidney long before labs turn abnormal

• Why nutrient deficiencies accelerate CKD—and how to correct them safely

• A crystal-clear, step-by-step system to master acid–base disorders in minutes instead of months

• Why dialysis increases oxidative stress, nutrient loss, immune suppression, and mortality

• How to apply functional medicine diagnostics to nephrology

• Evidence-based orthomolecular strategies to support renal repair and regeneration

WHO THIS BOOK IS FOR

• Nephrologists seeking deeper mechanistic understanding

• Internal medicine physicians managing CKD daily

• Medical students and residents who want to truly understand acid–base and renal physiology

• Nurse practitioners and physician assistants in renal care

• Functional and integrative medicine clinicians

• Researchers and educators

• Informed patients who refuse to accept inevitability

WHY THIS BOOK MATTERS NOW

Chronic kidney disease is one of the fastest-growing global health crises, yet prevention and reversal remain largely ignored. The New Functional Medicine Nephrology™ offers a new roadmap—one that aligns with biology, respects physiology, and restores hope.