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Summary of Jennifer A. Doudna & Samuel H. Sternberg’s A Crack in Creation
- Narrado por: Chad Louwerse
- Duración: 26 m
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Resumen del Editor
No time to read? Get the main key insights from this summary of Jennifer A. Doudna and Samuel H. Sternberg’s A Crack in Creation in just a short listen.
A few key insights from Chapter 1:
1. In 1983, biologist Jack Szostak discovered a repair mechanism for breaks in the double strand of DNA.
2. The famous structure of DNA is the double helix, which consists of two strands. In the repair procedure, it is broken by enzymes before a corrected copy of DNA is inserted, which facilitates the healthy copy’s incorporation.
3. By inducing a local double-strand break in the DNA, the genome can be corrected. When the break is introduced, the cell attempts to repair the damage, finding the synthetic gene ready at hand to replace the defective one that was broken.
4. With this discovery, a new challenge arose. Scientists had to find the right enzyme that would break the genome at the right site, singling out the right DNA sequence out of billions of similar sequences.
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The Deeper Genome
- Why There Is More to the Human Genome than Meets the Eye
- De: John Parrington
- Narrado por: John Lee
- Duración: 9 h
- Versión completa
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General4 out of 5 stars 106
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Narración:4 out of 5 stars 91
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Historia4 out of 5 stars 92
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.
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3 out of 5 stars
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Great Scientific Writing/ Wrong Narrator
- De Richard en 11-24-15
De: John Parrington
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- De: Juan Enriquez, Steve Gullans
- Narrado por: Rob Shapiro
- Duración: 10 h y 50 m
- Versión completa
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General4.5 out of 5 stars 202
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Narración:4.5 out of 5 stars 177
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Historia4.5 out of 5 stars 180
Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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5 out of 5 stars
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fascinating ideas and science
- De Joel en 07-04-15
De: Juan Enriquez, y otros
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Creation
- How Science Is Reinventing Life Itself
- De: Adam Rutherford
- Narrado por: Walter Dixon
- Duración: 6 h y 53 m
- Versión completa
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General4 out of 5 stars 43
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Narración:4 out of 5 stars 42
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Historia4 out of 5 stars 42
What is life? Humans have been asking this question for thousands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells, and whole organisms to create new ones that could never have previously existed on their own.
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5 out of 5 stars
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The Goldilocks book on what is life
- De Gary en 07-11-13
De: Adam Rutherford
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Welcome to the Microbiome
- Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You
- De: Rob DeSalle, Susan L. Perkins
- Narrado por: Stephen McLaughlin
- Duración: 7 h y 25 m
- Versión completa
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General4.5 out of 5 stars 36
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Narración:4.5 out of 5 stars 35
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Historia4.5 out of 5 stars 34
Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.
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5 out of 5 stars
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I learned so much from this book. I am happy.
- De Jonathan Miller en 09-08-18
De: Rob DeSalle, y otros
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- De: Daniel M. Davis
- Narrado por: Christopher Grove
- Duración: 7 h y 48 m
- Versión completa
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General4.5 out of 5 stars 51
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Narración:4.5 out of 5 stars 41
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Historia4.5 out of 5 stars 41
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- De Howard Sterling en 06-29-16
De: Daniel M. Davis
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p53: The Gene That Cracked the Cancer Code
- De: Sue Armstrong
- Narrado por: Elizabeth Jasicki
- Duración: 9 h y 55 m
- Versión completa
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General4.5 out of 5 stars 122
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Narración:4 out of 5 stars 106
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Historia4.5 out of 5 stars 104
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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5 out of 5 stars
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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The Gene
- An Intimate History
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 19 h y 22 m
- Versión completa
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General4.5 out of 5 stars 5,860
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Narración:4.5 out of 5 stars 5,145
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Historia4.5 out of 5 stars 5,098
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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5 out of 5 stars
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It's a Wonderful Book
- De JKC en 06-02-16
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
- Versión completa
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General4 out of 5 stars 148
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Narración:4.5 out of 5 stars 99
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Historia4 out of 5 stars 97
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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5 out of 5 stars
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The future of medicine
- De Ronald E en 04-12-10
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Life Unfolding
- How the Human Body Creates Itself
- De: Jamie A. Davies
- Narrado por: Napoleon Ryan
- Duración: 9 h y 56 m
- Versión completa
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General4.5 out of 5 stars 112
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Narración:4.5 out of 5 stars 100
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Historia4.5 out of 5 stars 100
Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die? Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem: How can something as large and complex as a human body organize itself from the simplicity of a fertilized egg?
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3 out of 5 stars
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Fascinating Biology ; Distracting Narration
- De Tim en 03-01-15
De: Jamie A. Davies
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- De: Kevin Davies
- Narrado por: Kevin Davies
- Duración: 16 h y 17 m
- Versión completa
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General4.5 out of 5 stars 76
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Narración:4.5 out of 5 stars 65
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Historia4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
- De Samuel Finlayson en 01-25-21
De: Kevin Davies
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
- Versión completa
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General4.5 out of 5 stars 117
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Narración:4.5 out of 5 stars 100
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Historia4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- De: Nathan H. Lents
- Narrado por: L.J. Ganser
- Duración: 7 h y 54 m
- Versión completa
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General4.5 out of 5 stars 2,252
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Narración:4.5 out of 5 stars 1,980
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Historia4.5 out of 5 stars 1,975
We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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4 out of 5 stars
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From Pointless Bones to Broken Genes to...Aliens?
- De Katy.LED en 12-04-18
De: Nathan H. Lents
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Know This
- Today's Most Interesting and Important Scientific Ideas, Discoveries, and Developments
- De: John Brockman
- Narrado por: Gabra Zackman, Dan John Miller
- Duración: 14 h y 39 m
- Versión completa
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General4 out of 5 stars 230
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Narración:4 out of 5 stars 202
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Historia4 out of 5 stars 199
Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?
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1 out of 5 stars
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Pete and Repeat and Re-repeat
- De Daniel L en 02-25-18
De: John Brockman
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How to Clone a Mammoth
- The Science of De-Extinction
- De: Beth Shapiro
- Narrado por: Coleen Marlo
- Duración: 7 h y 13 m
- Versión completa
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General4.5 out of 5 stars 126
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Narración:4.5 out of 5 stars 107
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Historia4.5 out of 5 stars 107
Could extinct species, like mammoths and passenger pigeons, be brought back to life? The science says yes. In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks listeners through the astonishing and controversial process of de-extinction.
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5 out of 5 stars
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Very Readable Take on a Complex Subject
- De John en 04-26-15
De: Beth Shapiro
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Herding Hemingway's Cats
- Understanding How Our Genes Work
- De: Kat Arney
- Narrado por: Kat Arney
- Duración: 8 h y 39 m
- Versión completa
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General4.5 out of 5 stars 53
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Narración:4.5 out of 5 stars 47
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Historia4.5 out of 5 stars 46
The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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2 out of 5 stars
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A non-scientists misguided interpretation
- De AraSevera en 05-15-16
De: Kat Arney
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Arrival of the Fittest
- Solving Evolution's Greatest Puzzle
- De: Andreas Wagner
- Narrado por: Sean Pratt
- Duración: 8 h y 29 m
- Versión completa
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General4 out of 5 stars 354
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Narración:4 out of 5 stars 298
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Historia4 out of 5 stars 299
In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over 15 years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.
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4 out of 5 stars
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Robustness makes for an interesting life and book
- De Gary en 11-29-14
De: Andreas Wagner
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How to Build a Dinosaur
- Extinction Doesn't Have to Be Forever
- De: Jack Horner, James Gorman
- Narrado por: Patrick Lawlor
- Duración: 6 h y 36 m
- Versión completa
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General4 out of 5 stars 101
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Narración:4.5 out of 5 stars 59
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Historia4.5 out of 5 stars 59
In movies, in novels, in comic strips, and on television, we've all seen dinosaurs - or at least somebody's educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on the blockbuster film Jurassic Park and a pioneer in bringing paleontology into the 21st century, teams up with the editor of the New York Times's Science Times section to reveal exactly what's in store.
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4 out of 5 stars
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Good book but misplaced title
- De Robert en 06-19-15
De: Jack Horner, y otros