Ever wished continuous glucose data didn’t require needles, adhesives, or a prescription? We sit down with Sabih Chaudhry, PhD, founder of AFON Technology, to unpack GlucoWare—a wrist-worn, noninvasive glucose wearable that uses low-power RF signals to read blood in near real time. Instead of piercing the skin, the device couples with your wrist, wakes every five minutes, pings a tiny signal, processes the reflection in under 200 milliseconds, and sends the data to your phone before going back to sleep. The result: familiar CGM-style insights without the interstitial lag, skin-tone limitations, or daily hassles.

We explore the journey from a rough “antenna and saline” lab hack to a robust, manufacturable design tested in environmental chambers and on robotic arms. Sabih explains how the team tackled motion noise, temperature swings, and material choices, all while building for scale and regulatory approval. We compare RF spectroscopy to optical approaches, discuss accuracy targets, and outline a roadmap aimed at non–insulin-dependent type 2 users first, with CE marking in sight and the FDA pathway running in parallel. Along the way, we dig into fundraising lessons, the choice to work with high-net-worth investors, and the newly inked partnership with a global manufacturer.

Beyond the tech, the conversation lands on impact. A painless, over-the-counter path to real-time glucose could help more people see spikes after meals, personalize diet and exercise, and improve time-in-range—key steps toward lowering HbA1c and reducing complications that strain health systems. The design leans fashion-forward to remove stigma, while the app mirrors clinical conventions so clinicians and users can speak the same language. Looking ahead, AFON’s modular electronics hint at future biomarkers—lactate, ketones, alcohol—and a smaller form factor suitable for kids, all pointing toward a smarter, more humane wearables era.

If you care about metabolic health, diabetes innovation, or the next leap in consumer-friendly biosensing, this one’s worth your queue. Subscribe, share with a friend who watches their glucose, and leave a review telling us what biomarker you want measured next.

https://afontechnology.com/

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Dr. Jamie Justice is the Executive Director of XPRIZE Healthspan - a $101 million, 7-year global competition to extend human healthspan by developing therapies that restore muscle, cognitive, and immune function by 10 to 20 years in people over 50. She is also a leading geroscientist and Adjunct Professor at Wake Forest University School of Medicine.

In this episode, Jamie breaks down the science of aging, the geroscience hypothesis, what 744 competing teams are building, and why the next few years could fundamentally change how we age.

We discuss:
- Jamie's journey from art scholarship and sports therapy to becoming a leading geroscientist
- The legendary Tom Johnson vs. Lynn Hayflick debate: are aging genes real, or is it all entropy?
- Why aging isn't like an oil tanker wearing out - the role of repair mechanisms and emergent complexity
- Steve Austad's quote: "The number of theories is inversely proportional to our understanding of a thing"
- The hallmarks and pillars of aging - the framework that gave the field testable targets
- Geroscience: targeting aging itself rather than one disease at a time
- Why we keep hitting a ~30% lifespan extension wall in mice
- Rectangularizing the curve: healthspan equals lifespan
- The Austad-Olshansky bet on a 150-year-old human - and why Jamie thinks that person is probably alive today
- Longevity escape velocity: why Jamie doesn't touch that question
- XPRIZE Healthspan: $101M, 744 teams, clinical trials in humans over 50
- The competition structure: semifinalists, finalists in August 2026, winners in 2030
- What's winning: metabolism/nutrient sensing and immune-targeting therapies lead
- The surprise entries: reprogramming teams ready for human trials sooner than expected
- Circadian-based teams, functional food approaches, and one team proposing to study nuns
- The upcoming XPRIZE in ovarian health - why it matters for both sexes
- How population-level shifts require more than individual breakthroughs

Guest: Dr. Jamie Justice, Ph.D.
Executive Director, XPRIZE Healthspan | EVP, Health Domain, XPRIZE Foundation
Adjunct Professor, Wake Forest University School of Medicine
XPRIZE Healthspan: xprize.org/competitions/healthspan

Mentioned in this episode:
- Peter Diamandis - XPRIZE founder
- Steve Austad - The "Dos Equ

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Get 120 Biomarkers for $99 and CT Calcium scans anywhere in the US. https://www.vitalsvault.com/

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Dr. Heather Sandison was told in medical school that suggesting you could help someone with Alzheimer's was promoting false hope. Then she ran a clinical trial and 74% of participants with measurable cognitive impairment improved in six months.

In this episode, Dr. Sandison breaks down the five things you can start doing today to protect your brain - no doctor visit required - and explains why the conventional approach to Alzheimer's has failed, what her clinical trial revealed, and how she's working to make Alzheimer's optional in this generation.

We discuss:
- Why the amyloid hypothesis has failed after billions of dollars and decades of research
- The clinical trial results: 74% of cognitively impaired participants improved in 6 months
- Five actionable brain health strategies: blood sugar control, sleep, exercise, toxin reduction, and stress management
- Why continuous glucose monitors (CGMs) are a powerful first step
- The critical role of sleep and glymphatic brain detox in preventing neurodegeneration
- Dual-task exercise: why pickleball, dancing, and Pilates beat the treadmill for brain health
- Toxins as a causal factor: mercury, glyphosate, microplastics, and mycotoxins
- APOE4 genetic risk: what it means and what you can do about it starting young
- The ketosis connection: a patient who recognizes his grandkids in ketosis and doesn't without it
- Comprehensive functional medicine testing: what to ask for and why
- Glyphosate in U.S. grains: why people can eat bread in Europe but not America
- Marama: the residential memory recovery program changing Alzheimer's care
- Why Alzheimer's, diabetes, cancer, and mental illness share the same root causes
- Dr. Sandison's one request: optimize your sleep tonight

Guest: Dr. Heather Sandison, ND
Website: Solcere Health (solcere.com) | Marama (myvibrantvita.com)
Book: "Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health" - NYT Bestseller, available on Amazon and wherever books are sold

Mentioned in this episode:
- Dr. Dale Bredesen - Bredesen Protocol
- Chris Palmer, MD - Brain Energy / Ketogenic therapy for mental illness
- Thomas Seyfried - Cancer as a metabolic disease
- P-tau 217 - Early Alzheimer's biomarker
- Stelo and Lingo - Over-the-counter continuous glucose monit

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