Leslie Kenny was told in her 30s that she had five years to live. Diagnosed simultaneously with lupus, rheumatoid arthritis, and Hashimoto’s thyroiditis — and told to give up her dream of having children — she did what true Betties do: she refused the prognosis, threw everything she had at it, and got to work. Now 60 years old, Leslie reports a biological age of 21. She is autoimmune disease-free. And she naturally conceived a child at 43.

Her recovery journey led her to collaborate with University of Oxford scientists and to discover spermidine — a naturally occurring, food-derived longevity compound that was hiding in plain sight. It’s been in our food for millennia, it’s in breast milk, and it’s in every plant on earth. And it addresses 9 of the 12 hallmarks of ageing identified by science as the root causes of why we get older.

For 20% off Primeadine, go to: https://www.oxfordhealthspan.com/DRSTEPHANIE

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(4:00) What Is Spermidine and Why Do We Lose It?
(8:00) Autophagy, Hair, Nails & the Biological Dashboard
(17:00) The 12 Hallmarks of Ageing, Explained for Real Life
(23:00) mTOR, Muscle Loss, and Why Spermidine Is Different
(27:00) Food Sources, Dosage & Lifestyle Levers
(38:00) Leslie's Story: The Diagnosis, the Prognosis, the Refusal
(55:00) IVIG, Trauma Therapy & the Surprise Pregnancy at 43
(1:18:00) Femspan, Future Research & Where to Find Leslie
(1:22:00) The After-Party Thoughts with Dr. Stephani

Resources mentioned in the Episode can be found at: https://drstephanieestima.com/podcasts/ep464

We couldn’t do it without our sponsors:

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

You've been lied to. Not by your body — by the system that profits from you believing it's broken. Dr. Stephanie names the real villain behind decades of failed diets, shrinking goals, and body distrust: the wellness industrial complex that told you skinny equals healthy. You're not broken - you were just given the wrong map. Here is the right one!

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(2:00) The Villain: Diet Culture & the Wellness Industrial Complex
(7:00) What Chronic Under-Eating Does to Your Body
(9:00) Debunking the Bulky & Toned Myths
(15:00) The Psychology of Shrinking
(17:00) Your Body Didn’t Betray You. It Protected You
(21:00) How to Rebuild: Strength, Recovery & Mobility
(26:00) Fuel the Build: Eating for the Body You Want
(34:00) You’re Building a 40-Year Asset

Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep463

We couldn’t do it without our sponsors:

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YOUNG GOOSE - More resilient. More hydrated. More responsive. This is skin quality skincare. Go to https://younggoose.com/better and use code BETTER for 10% off your first purchase

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

If you've ever sat in a doctor's office describing brain fog, mood swings, terrible sleep, and a body that no longer responds to anything you try — only to be sent home with a shrug and maybe an antidepressant — this one's for you. Dr. Mary Claire Haver, Board-Certified OBGYN and Certified Menopause Specialist, is back for round two, and she came prepared.

In this episode, she breaks down the hormonal wildfire she calls 'The Zone of Chaos,' explains why perimenopause looks nothing like what your doctor was trained to treat, and gives you the actual language to walk into your next appointment and finally get some answers. Buckle up.

Episode Overview (timestamps are approximate):
(0:00) Intro/Teaser
(5:00) The Zone of Chaos
(9:00) How Do You Know You're in Perimenopause?
(13:00) "I Don't Feel Like Myself" - The Universal Symptom
(15:00) 10 Doctors, Polypharmacy & a Hysterectomy
(17:00) How to Get Answers
(19:00) Your Brain on Perimenopause
(23:00) The ADHD Connection
(26:00) Bone Density & Muscle Mass
(29:00) Calming the Chaos, Not Replacing What's Lost
(44:00) What Mary Claire Actually Does
(53:00) Fasting, Menowashing & Your Bull$h!t Radar
(56:00) A Letter to My 35-Year-Old Self
(1:00:00) After Party: Dr. Stephanie's Takeaways

Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep462/

We couldn’t do it without our sponsors:

ONESKIN - Harness the power of peptides for fuller hair and glowing skin. Save 15% at https://oneskin.co/better with code BETTER.

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BIOPTIMIZERS - Magnesium Breakthrough contains multiple types of magnesium plus cofactors like B6 to enhance absorption. Visit https://bioptimizers.com/better and use code BETTER to save 15%.

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P.S. When you're ready, here are two ways Dr. Stephanie can help you:

Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.

Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.