Metastatic BRCA-Negative, Triple-Negative Breast Cancer — An Interview with Prof Peter Schmid on Optimal Management (Companion Faculty Lecture)

Featuring a slide presentation and related discussion from Prof Peter Schmid, including the following topics:

• Evolution of the therapeutic landscape for metastatic triple-negative breast cancer; age of immunotherapy (0:00)
• Case: A woman in her early 40s with no actionable mutations (7:29)
• Evolution of antibody-drug conjugates (ADCs) in the management of metastatic breast cancer (11:13)
• TROP2-directed ADCs (15:22)
• Case: A woman in her early 50s with PD-L1-negative, HR-negative, HER2-low de novo metastatic breast cancer (20:21)
• Novel strategies utilizing approved and investigational ADCs (23:28)
• Case: A woman in her early 60s with loss of HER2 expression on disease progression (31:39)
• ADCs in combination with immunotherapy (32:51)

CME information and select publications