Dr. Constantine was a profoundly learned and eloquent preacher, known for his mastery of Latin, Greek, Hebrew, and other languages, as well as various sciences. He was immensely popular, consistently drawing large crowds because of his persuasive delivery and the perceived soundness of his teachings. After being confirmed in Protestantism by Dr. Aegidio, he began to preach boldly doctrines that aligned with "Gospel purity" and were free from what he saw as errors of the Romish Church. He also forcefully preached against simony, which offended many of his superiors. His bold doctrines and popularity created many enemies among Roman Catholics and superiors, some of whom were determined to destroy him.

He was appointed as a reader at a school for divinity lectures, where he expounded on books like Proverbs, Ecclesiastes, and Canticles, and was beginning the Book of Job when he was seized by the inquisitors. Initially, his cautious answers prevented explicit charges, but the discovery of his private books and papers with Isabella Martin, following a servant's betrayal and his son's mistake, provided the necessary evidence. Confronted with his writings, Constantine justified the doctrines they contained, affirming his adherence to Gospel truth. This led to his imprisonment for over two years. He ultimately died in prison from a bloody flux, but the Inquisition continued its process against his remains, and his body was publicly burnt at a subsequent auto da fe.

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