If you want to start with the works of Tim Powers, don't start here. This is volume 3 of an extended story. Start with either On Stranger Tides, The Stress Of Her Regard, or Declare. If, at the end, you decide you liked what you read and were glad you pushed through his sometimes difficult openings (as I was, on all three), then tackle Last Call, Expiration Date, and Earthquake Weather.
But be warned. Powers creates some really weird worlds into which you get sucked. He has a terrific capacity to capture the feeling of an alien reality permeating our own, and by the end of many of his books you will be thoroughly weirded-out. But in this case the weirdness intensifies over all three books.
This book is weird. Really weird. If you haven't read the first two, you don't have a prayer (even to Dionysus) of even following what's going on. But if you have, this is a heavy slog.
I'm not sorry I read it, but I did read the other two, and not so long ago that I've forgotten them. But this one was hard to read. I kept looking at it and thinking, this is just too weird. But not quite, not quite enough for me to give up. But it's weird.
So my advice is, come at Tim Powers from an oblique angle. If you like the other stuff, then tackle the Fault Lines trilogy. You won't be sorry you finished it, but this volume 3 will have been more work than many another book you could name. Yet still worth the effort. Because no one can suck you into weirdness like Tim Powers.