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A Fatal Inheritance
- How a Family Misfortune Revealed a Deadly Medical Mystery
- Narrated by: Roger Wayne
- Length: 9 hrs and 25 mins
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Publisher's summary
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
Critic reviews
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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How could a 66-year-old grandmother, who gave her life to helping people with their health, become the subject of a malicious smear campaign which resulted in her being classified as a serious threat to public health in Australia? This book exposes the hypocrisy of the organization Friends of Science in Medicine who act as 'friends of science', but are in reality pharmaceutical apologists and the 'Enemies of Truth in Medical Science'. Barbara became collateral damage in the war on any dissent from mainstream medical dogma.
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What a story!
- By Danielle on 05-26-24
By: Michael O'Neill
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Committed
- On Meaning and Madwomen
- By: Suzanne Scanlon
- Narrated by: Suzanne Scanlon
- Length: 10 hrs and 13 mins
- Unabridged
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When Suzanne Scanlon was a student at Barnard in the '90s, grieving the loss of her mother—feeling untethered and swimming through inarticulable pain—she made a suicide attempt that landed her in the New York State Psychiatric Institute. After nearly three years and countless experimental treatments, Suzanne left the ward on shaky legs. In the decades it took her to recover from the experience, Suzanne came to understand her suffering as part of something larger.
By: Suzanne Scanlon
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But You Look So Normal
- Lost and Found in a Hearing World
- By: Claudia Marseille
- Narrated by: Becky Parker
- Length: 9 hrs and 21 mins
- Unabridged
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Story
But You Look So Normal is the inspiring story of a life affected, but not defined, by an invisible disability. It is a journey through family, loss, shame, identity, love, and healing as Claudia finally, joyfully, finds her place in the world.
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Ambition Monster
- A Memoir
- By: Jennifer Romolini
- Narrated by: Jennifer Romolini
- Length: 9 hrs and 32 mins
- Unabridged
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After years of relentlessly racing up the professional ladder, Jennifer Romolini reached the kind of success many crave: a high-profile, C-suite dream job, a book well-received enough that reporters wanted to know the secrets to her success, and a gig traveling around the country giving speeches on “making it.” She had a handsome and clever husband, a precocious child. But beneath this polished surface was a powder keg of unresolved trauma and chronic overwork. It was all about to blow.
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Fi
- A Memoir
- By: Alexandra Fuller
- Narrated by: Alexandra Fuller
- Length: 6 hrs and 24 mins
- Unabridged
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Story
It’s the middle of the summer before her fiftieth birthday and Alexandra is just barely hanging on. Grieving her father and pining for her home country of Zimbabwe, chafing and straining against the stresses and strictures of midlife as a mother and ex-wife, and piecing her way through a disastrous relationship with a younger woman that lurches and buckles, but never quite breaks. And then—suddenly and incomprehensibly—her son Fi, at 21 years old, dies in his sleep. What happens next is what Alexandra details in this book.
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Heartbreaking and beautiful.
- By Kristin Kline on 05-25-24
By: Alexandra Fuller
What listeners say about A Fatal Inheritance
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- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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1 person found this helpful