Fifteenth-century Spain is rent with intrigue and threatened by civil war. Here, the young Isabella becomes the pawn of her half-crazed mother and a virtual prisoner at the licentious court of her half-brother, Henry IV. At just sixteen years old, is she already fated to be the victim of the Queen's revenge, the Archbishop's ambition and the lust of lecherous Don Pedro Girón?
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Married to Ferdinand after numerous fears and disappointments, Isabella triumphs over every danger, convinced of her own destiny. With the might of Portugal humbled, the court of the Sovereigns sees the rise of Torquemada and the establishment of the dreaded Inquisition. It also witnesses the coming of Columbus, who leaves the woman he loves to make a dream reality.
Isabella and Ferdinand rule over a newly united Spain, steadfast in their determination to build a powerful state. During the final years of Isabella’s reign, Ferdinand looks to his daughters to further his ambitions, but his wife finds herself torn between his brilliant plans and her love for her children. As events unfold, the sovereigns begin to feel that there must be a curse on the royal house – misfortune strikes at the heart of their family and tragedy after tragedy befalls the Daughter of Spain.