Ever since the death of her fiance, Meredith Mancuso has shrunk from the world. Even with her successful writing career, she's not motivated to work. When her sister, Monica, begs for a favor, Meredith wants nothing more than to say no. But she's ultimately roped into pet-sitting an orphaned Yorkshire terrier named Prozac. Blessed with spiritual wisdom and a high IQ, Prozac is an active pet-therapy dog. To heal broken-hearted Meredith, he rallies his fan club at Evergreen Gardens.