Even as a teenager, Dupree "Numbers" Wallace had a keen mind for math. Whether he was getting good grades on his math tests or adding up the change he earned making grocery runs for his neighbors, Numbers came out ahead more times than not. When Crispy Carl, the flyest pimp in the hood, gets wind of the young man's gift, the old cat takes him under his wing. Numbers quickly finds himself deep in his Brooklyn neighborhood's numbers racket, as well as dice and card games, gaining a reputation for his hustle. But when his little sister gets cancer, Numbers is forced to bump up his game to the world of drugs in order to pay for her treatment.