Salute to Adventurers takes place in the 1680s. It begins as the hero, Andrew Garvald, on his way to Glasgow, takes a cut across the moors. There he meets Elspeth Blair and a religious fanatic known as Muckle John Gib. Later Andrew encounters Ninian Campbell, coming to Campbell's aid when he is attacked by ruffians in a Glasgow back street. Andrew is sent by his uncle - as his merchant representative - to Virginia, where he initially experiences hostility because of his attempts to reform trading practices.