• de-CIPHERing Infectious Disease

  • By: CIPHER
  • Podcast
de-CIPHERing Infectious Disease  By  cover art

de-CIPHERing Infectious Disease

By: CIPHER
  • Summary

  • ”de-CIPHERing Infectious Disease” explores the cutting-edge interdisciplinary research happening at UNC Charlotte’s CIPHER Research Center. Each episode features an in-depth interview with one of CIPHER’s researchers, allowing them to discuss their background, current projects, and the exciting team science approach they take to tackle complex issues at the intersection of health, environment, data science, genomics, infectious disease, and more. Host Ian Binns engages the researchers in accessible conversations that dive into the science behind their work while also highlighting the collaborative spirit and diverse expertise that makes CIPHER’s ”One Health” philosophy so powerful. From evolution and phylogenetics to machine learning, drug discovery, and preventing the next pandemic, ”de-CIPHERing Infectious Disease” offers listeners a window into the innovative solutions being pioneered to address global challenges.
    Copyright 2024 All rights reserved.
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Episodes
  • Plant Pathology with Dr. Morgan Carter
    Jun 4 2024
    Episode 4

    In this enlightening episode, we sit down with Dr. Morgan Carter, a passionate plant pathologist and academic, to explore the immune systems of plants. Dr. Carter shares her journey into the field, discussing the challenges and triumphs of studying plant-microbe interactions. We delve into the impact of governmental policies on scientific research and the importance of science communication. It was a wonderful conversation, and we think you're going to love it.

    Find out more at cipher.charlotte.edu.

    Key Takeaways
    • Plant pathology is the study of how plants have immune systems and interact with pathogens.
    • Understanding bacterial-fungal interactions in plants is crucial for plant health in agriculture and the environment.
    • Morgan Carter's lab focuses on molecular host-bacterial-fungal interactions and conducts both wet lab experiments and computational analysis.
    • Fungi have various benefits, including their role in food production and their symbiotic relationships with plants.
    • The concept of One Health emphasizes the integration of different fields to address health risks.
    • Research findings can sometimes challenge preconceived notions and highlight the role of evolution in shaping organisms.
    • Engaging in policy discussions and outreach is crucial for ensuring that scientific research is used effectively and that regulations are informed by scientific knowledge.
    • Creating a supportive and inclusive environment for students, prioritizing mentorship, and recognizing the importance of work-life balance are essential for a successful academic career.
    • Leaving a legacy in academia involves not only making scientific discoveries but also mentoring and supporting future scientists.

    This podcast was produced and edited by Zack Jackson CIPHER is a proud part of UNC Charlotte who holds all rights to the content created by this podcast

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    1 hr and 1 min
  • Marine Biology with Dr. Adam Reitzel
    May 21 2024
    Episode 3

    In this episode, host Dr. Ian Binns interviews Dr. Adam Reitzel, a marine biologist and co-director of CIPHER at UNC Charlotte. Dr. Reitzel discusses what sparked his early interest in science, his journey into becoming a marine biologist despite growing up far from the ocean, and the fascinating world of sea anemones that are the focus of his research. He shares insights into the inner workings of his lab, the importance of mentorship, examples of surprising research findings, and how his work connects to the mission of predicting health and environmental risks through CIPHER. The conversation covers topics like host-microbe interactions, biodiversity, science communication, and the potential future role of AI in understanding and protecting the oceans.

    Find out more at cipher.charlotte.edu.

    Key Takeaways
    • The impact of a mentor can be pivotal in shaping a career in science.
    • Marine biology focuses on the study of marine invertebrates and coastal environments.
    • A marine biologist conducts fieldwork, molecular analysis, and computational work to understand marine organisms.
    • Effective mentorship involves listening, providing constructive feedback, and supporting individual passions.
    • Understanding the health of organisms in oceanic environments is a key aspect of marine biology research.
    • Organisms have complex immune systems that evolve quickly, similar to humans.
    • Understanding biodiversity and environmental risks is crucial for One Health.
    • Team science brings together experts to solve problems collaboratively.
    • Curiosity and learning from others are essential for scientific progress.
    • Research findings can sometimes be surprising and challenge existing assumptions.
    • Depictions of sea anemones in popular culture can spark interest in marine biology.
    • Artificial intelligence has the potential to enhance research and experimental design.
    • Goals for the future include fostering new scientists and advancing host-microbe interactions.
    • Engaging with the public and promoting science communication are important responsibilities for researchers.

    This podcast was produced and edited by Zack Jackson CIPHER is a proud part of UNC Charlotte who holds all rights to the content created by this podcast

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    52 mins
  • Bioinformatics with Dr. Dan Janies
    May 7 2024
    Episode 2

    In this episode, we are joined by co-director of CIPHER and bioinformatics expert: Dr. Dan Janies. He discusses his background and work in using computational methods and genomic data to study infectious diseases. He explains how he traced the origins of the SARS coronavirus to bats and used bioinformatics to track the spread of diseases like SARS, bird flu, and COVID-19 variants. Dr. Janies describes innovating techniques like projecting phylogenetic trees onto Google Earth to visualize disease movement and calculating protein structures to predict immune evasion. He shares his vision for "functional molecular epidemiology" to not just detect mutations but understand their impacts, and emphasizes the need for constant genomic surveillance to stop outbreaks before they become pandemics. This work is truly interdisciplinary and cutting edge.

    Find out more at cipher.charlotte.edu.

    Key Takeaways
    • Bioinformatics is a field that combines computer science and biology to analyze and compare genomes.
    • Comparing genomes of viruses and bacteria helps understand their evolution and the impact of mutations.
    • Tracing the origins of infectious diseases can provide insights into their transmission and help prevent future outbreaks. Supramap is a tool developed by Dan Janies that projects virus trees onto Google Earth, allowing researchers to study the movement and evolution of viruses.
    • Functional molecular epidemiology focuses on understanding the impact of mutations in viruses and their implications for public health.
    • Artificial intelligence, particularly the AlphaFold program, has revolutionized structural biology and the ability to accurately and quickly calculate protein structures.
    • There is a need for a proactive approach to monitoring and preventing pandemics, using genomics and computational tools to detect and respond to emerging infectious diseases.
    • Collaboration and capacity building are essential in the field of bioinformatics and infectious disease research, as researchers work together to develop best practices and share knowledge.

    This podcast was produced and edited by Zack Jackson CIPHER is a proud part of UNC Charlotte who holds all rights to the content created by this podcast

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    1 hr and 3 mins

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