What these strange conditions, including fatal familial insomnia, kuru, scrapie, and mad cow disease, share is their cause: prions. Prions are ordinary proteins that sometimes "go wrong", resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA. And the diseases they bring are now spreading around the world.
In The Family That Couldn't Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion's hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story's connection to human greed and ambition, from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out.
The biologists who have investigated these afflictions are just as extraordinary. They include Daniel Carleton Gajdusek, a self-described "pedagogic pedophiliac pediatrician" who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.
©2006 D.T. Max; (P)2006 Tantor Media, Inc.
"Very timely and compellingly written." (Booklist)
This has become one of my favorite non-fiction books on audible. If you enjoyed "Splendid Solution", "The Great Influenza" or "Germs" you will love this one. It may not have the humor or entertainment value of "The Omnivore's Delimma" but the author does a fine job of weaving personal stories with science to create a fascinating story. This is a great introduction to Mad Cow and other prion diseases, and also provides a distrubing account of how governments bumble their way through such outbreaks.
Grover Gardner also performs another excellent reading. In my opinion, Gardner is by far the top narrator for any material that has any scientific or technical content. His voice moves gracefully over the text - always with the right nuance and pronunciation - allowing the listener to become quite captivated by the story.
Wonderfully written account of prions: the diseases associated with them; the nobel laureates who study them; people affected; and how the problem began, was discovered, and has spread. Like a PBS special and a novel rolled into one, you learn quite a bit while being thoroughly entertained. A page turner.
I know others have put down this book because it isn't just about the life of the family that couldn't sleep. True, it is a book about prions, and tells of all of the research in many fields and into many disorders. But, scientific though it is, it really is facinating and quite easy to follow along with and understand. The reader does have a bit of an annoying habit of ending every sentence the same way with a strange inflection, but you'll get used to it, or at least learn to ignore it.
This book is a wonderful piece for people interested in the medical field. It offers a wonderfully accessible explanation of prion diseases combined with a human touch and a fabulous narrator voice. Highly recommended!
Any one with a family member with a disability that is neurological in origin will appreciate this book. The author's final chapter says it all. Great narrator.
I love (audio)books.
I learned a lot of prion from this book. The story is good and the writer tries to entangle the other kinds of prion disease. It's not just about the family that couldn't sleep. I hope that there will be a cure for prions soon.
I picked this right after starting the short-story anthology Zombies vs. Unicorns (zombie fiction sometimes blames prions) on Kindle. Fun connection. As to this book, it was a great story, interesting science, kept a good pace, and gave me pause (yet again) about eating factory-farm meat...
Wow, I had no idea how much prions affected our world! From cannibals, to mad cows, to inherited conditions. Mad cow hit the head lines and we all learned some, but this book exposes and explains the stories behind the headlines, and why these diseases are so scary. Nothing graphic, good language, highly recommend this book to all interested in disease, science, and a good listen.
There is a family of disorders that eat away the brains of their victims, whether they are humans or livestock. I know, sounds depressing, but the search for the cause of these disorders is utterly fascinating. There are enough personal stories to make it feel a bit like a novel at times, but it is actually a true scientific detective story. There are brilliant and odd scientists, conflicted and disorganized governments, and some deeply sad and touching personal stories. There are also enough ironic and even humorous moments to keep things from ever feeling too heavy. I particularly liked hearing that a researcher had for years kept a flock of infected sheep on the roof of a London hospital. I've been passionate about reading up on these prion diseases for years, and I still found lots in this book that was new to me. I've shared this book with people who were unfamiliar with prions, and they have found it captivating and easy to understand.
This was a great book. It had very good information and was well written. Fascinating biological information was expressed thoughtfully. I have a degree in biology and still felt that the information was in depth, but would be appropriate for any listener.
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