What these strange conditions, including fatal familial insomnia, kuru, scrapie, and mad cow disease, share is their cause: prions. Prions are ordinary proteins that sometimes "go wrong", resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA. And the diseases they bring are now spreading around the world.
In The Family That Couldn't Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion's hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story's connection to human greed and ambition, from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out.
The biologists who have investigated these afflictions are just as extraordinary. They include Daniel Carleton Gajdusek, a self-described "pedagogic pedophiliac pediatrician" who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.
©2006 D.T. Max; (P)2006 Tantor Media, Inc.
"Very timely and compellingly written." (Booklist)
This has become one of my favorite non-fiction books on audible. If you enjoyed "Splendid Solution", "The Great Influenza" or "Germs" you will love this one. It may not have the humor or entertainment value of "The Omnivore's Delimma" but the author does a fine job of weaving personal stories with science to create a fascinating story. This is a great introduction to Mad Cow and other prion diseases, and also provides a distrubing account of how governments bumble their way through such outbreaks.
Grover Gardner also performs another excellent reading. In my opinion, Gardner is by far the top narrator for any material that has any scientific or technical content. His voice moves gracefully over the text - always with the right nuance and pronunciation - allowing the listener to become quite captivated by the story.
Wonderfully written account of prions: the diseases associated with them; the nobel laureates who study them; people affected; and how the problem began, was discovered, and has spread. Like a PBS special and a novel rolled into one, you learn quite a bit while being thoroughly entertained. A page turner.
I know others have put down this book because it isn't just about the life of the family that couldn't sleep. True, it is a book about prions, and tells of all of the research in many fields and into many disorders. But, scientific though it is, it really is facinating and quite easy to follow along with and understand. The reader does have a bit of an annoying habit of ending every sentence the same way with a strange inflection, but you'll get used to it, or at least learn to ignore it.
I'm an obsessive reader of science fiction, psychological thrillers, and anything that might distract me from the misery that is exercise.
This book is a wonderful piece for people interested in the medical field. It offers a wonderfully accessible explanation of prion diseases combined with a human touch and a fabulous narrator voice. Highly recommended!
among the top books i have listened to on audible
well researched, up to date, and narratives that bring you to understand the lives affected by those afflicted with prion disease.
a fatal insomnia
a unique historical perspective on a rare inherited genetic disorder that strikes its victims with symptoms of a lethal insomnia in their most productive years. Also, tied into this narrative of the familial disease, is its link to the prion disease of mad cow, or CJD. The research documented by D.T. Max, brings to light cases of individuals affected by CJD that has occurred in the U.S. and the U.K. which can only be explained prions from contaminated beef. That the threat still exists, and human cases are being suppressed by the USDA, should make anyone concerned about the potential impact of circulating prions in our beef supply.
It is surprising how fascinating a medical mystery can be. I was hanging on every word. I was terrified, but still could not stop listening.
I picked this right after starting the short-story anthology Zombies vs. Unicorns (zombie fiction sometimes blames prions) on Kindle. Fun connection. As to this book, it was a great story, interesting science, kept a good pace, and gave me pause (yet again) about eating factory-farm meat...
College English professor who loves classic literature, psychology, neurology and hates pop trash like Twilight and Fifty Shades of Grey.
look into the frightening world or prion diseases.
Any one with a family member with a disability that is neurological in origin will appreciate this book. The author's final chapter says it all. Great narrator.
I wouldn't say this was a terrible book. I would say it was a mediocre book. It was essentially a medical textbook and it read like one. I usually enjoy books about these subjects, but there was something about this book that I just can’t put my finger on that leaves me with this "it's just average" feeling. Yes, I did learn something, which I always enjoy, but you certainly need to pay attention to every single sentence in this book or you will be totally lost. It was very heavy on the science, but not so much that anyone with a decent public education couldn’t absorb. I usually find myself searching online while listening to books like this to learn even more about the subject, but this book just didn’t evoke that kind of interest for me.
The only saving grace is the narration. I think that is the only thing that kept me from returning the book at the halfway point. Grover Gardner made it worth holding out to the end; he’s just that good! I'm debating if I'll listen to this book again to see if my opinion changes?
Ironically, this book has discovered the cure for the Family That Couldn’t Sleep; they just need to listen to this book. Put me to sleep in about 10 minutes every night.
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