Around the world, black handprints are appearing on doorways, scorched there by winged strangers who have crept through a slit in the sky. In a dark and dusty shop, a devil's supply of human teeth grown dangerously low. And in the tangled lanes of Prague, a young art student is about to be caught up in a brutal otherwordly war. Meet Karou. She fills her sketchbooks with monsters that may or may not be real; she's prone to disappearing on mysterious "errands"; she speaks many languages - not all of them human; and her bright blue hair actually grows out of her head that color.

In Beatrice Prior's dystopian Chicago, society is divided into five factions, each dedicated to the cultivation of a particular virtue - Candor (the honest), Abnegation (the selfless), Dauntless (the brave), Amity (the peaceful), and Erudite (the intelligent). On an appointed day of every year, all sixteen-year-olds must select the faction to which they will devote the rest of their lives. For Beatrice, the decision is between staying with her family and being who she really is - she can't have both. So she makes a choice that surprises everyone, including herself.

"Ninety-five days, and then I'll be safe. I wonder whether the procedure will hurt. I want to get it over with. It's hard to be patient. It's hard not to be afraid while I'm still uncured, though so far the deliria hasn't touched me yet. Still, I worry. They say that in the old days, love drove people to madness. The deadliest of all deadly things: It kills you both when you have it and when you don't."

Ever since the gods of Ancient Egypt were unleashed in the modern world, Carter Kane and his sister, Sadie, have been in trouble. As descendants of the House of Life, the Kanes have some powers at their command, but the devious gods haven’t given them much time to master their skills at Brooklyn House, which has become a training ground for young magicians. And now their most threatening enemy yet—the chaos snake Apophis—is rising.