I enjoyed the book and thought that it was written in an accessible and entertaining manner. The points are familiar and not surprising to those working in the field. However, I'm a psychologist and many of my patients are not aware of the extreme impact that lack of exercise, stress and sleep have on the brain and your ability to think.
I believe that this book was written with the intent to make work and school environments more human places - that support learning and creativity. Many people berate themselves because they simply feel like they don't measure up when it's really an environment that is bad for brains.
Medina has made an excellent case for changing the world for the better and I hope that teachers and managers take notice.
I didn't find the book particularly deep and didn't offer any original insights. The essence of the book basically works out to be that you are here to serve God and discover his will for you and then go out and try to preach to as many people as possible. If you are not a Christian there is really no secular message or process here for you (you might want to check out the Art of Happiness by the Dalai Lama which I did find rather helpful-and it didn't matter whether you were Buddhist or not).
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