I was a little ambivalent about trying one of these "Great Courses" on audio, especially with references to diagrams and such, but the instructor promised at the beginning that you could follow along at home without needing the pictures, and he was right, though there are points at which it might benefit a listener to pause the the lecture long enough to look up the diagram if you are having trouble visualizing what he describes.
This is a course on advanced physics for people who are not physics students. All that high-level stuff like General and Special Relativity, the three fundamental forces, quantum mechanics, why nothing can go faster than light, how time dilation works, what is really going on with black holes and whether "wormholes" really exist (answer: there is currently no actual evidence of them, we just know that the math supporting the possibility of their existence works) and a dozen other topics for any long-time science fiction reader.
And that is why I downloaded this course, because I haven't had a physics class since high school, and I've had only a brief survey course on quantum mathematics, but I wanted to understand the physics behind relativistic travel and the formation of the universe and quantum theory and all that jazz well enough to feel educated when I read science fiction that tries to be "hard" (and even to have a better grounding for any SF I might write myself...).
I would say this course works very well for that purpose. The professor promises that the math is minimal, so at several points he handwaves the formulas, saying "Trust me (but go look it up if you want to really understand it)" but assures us that the concepts he explains require no more than high school algebra, for the most part, and this was also true. So this is a very "math light" physics course for non-physicists, and thus for someone who is a veteran of hard SF there won't be much here in the way of new concepts - you have probably read Heinlein's Time for the Stars in which a pair of telepathic twins conduct the famous "twin experiment" with one twin staying on Earth getting old while the other twin sets off on a journey in a spaceship traveling at near-lightspeed. And you've read lots of stories about black holes and how they "slow time" as you approach the event horizon. (Go see Interstellar - it's a fantastic movie.) And you know that pure matter-energy conversion would be a billion times more efficient than nuclear fusion, if we could do it. And you've heard of Schroedinger's Cat and how supposedly we could use paired qubits to achieve faster-than-light communication (we can't). And gravity warps time and space, and light is a particle and a wave (and in fact so is all matter, really), and Einstein refused to believe God rolled dice with the universe.
All that is covered here, and at the end of it, you'll understand it better, conceptually, but obviously this cannot replace an actual physics course and if you want to really, really understand it, you'd have to actually get deeper into the math. I now have a better understanding of what physics says about General and Special Relativity and black holes and time travel and quantum entanglement. Do I really, thoroughly understand it? You'll probably find several points Professor Wolfson covers need to sit with you awhile, and some stuff you'll really have to read more deeply to fully "get it." But you can get the gist adequately from this course.
So, this course will not work as a substitute for taking an actual physics class. It probably won't even work very well as a primer. But if you're just a layman who already has some idea of the stuff you've been reading about in science fiction but you want to know more about it, you'll find this course quite valuable, and if you actually don't know any of this stuff, it will probably blow your mind.
The lecturer builds up his topics very carefully, starting with what ancient astronomers and physicists knew, all the way back to Aristotle. There is a lot of physics history here, so you'll get your Copernicus and Galileo and Newton and Maxwell and Bohr and of course Einstein, and that part is also quite interesting, as there is just a little bit of biographical information about each person, but more importantly, what exactly they figured out and how and how it changed what was known up to that point in time.
Overall, well worth the investment in listening to.