In an attempt to find out, Mary Roach brings her tireless curiosity to bear on an array of contemporary and historical soul-searchers: scientists, schemers, engineers, mediums, all trying to prove (or disprove) that life goes on after we die. She begins the journey in rural India with a reincarnation researcher and ends up in a University of Virginia operating room where cardiologists have installed equipment near the ceiling to study out-of-body near-death experiences.